Malaysian Node of the Human Variome Project
“The Malaysian Node of the Human Variome Project represents the Malaysian node of HVP which comprises 69 researchers from 15 Malaysian universities and institutes. The launch of the Malaysian node of the Human Variome Project was held on 9th October 2010 at the Medical Faculty of Universiti Putra Malaysia, Serdang. The event was officiated by Dr. Vilasini A/P Pillai N.V. who represented Professor Emeritus Dato’ Zakri Abdul Hamid, the Science Advisor to the Prime Minister of Malaysia..."
Zilfalil Bin Alwi, MBBS, PhD
The ethnic population of Malaysia comprises of 50.4% Malays and 11% other indigenous group who form the majority of the population. The other major ethnic groups are Chinese and Indians.
The proposed genome mapping of these ethnicities will illustrate the genetic map of the country's migration history and the extent of genetic similarities between the various ethnic populations. The mapping will also provide a genome database for a study of common diseases in Malaysia as well as its ethical, legal and social implications on our society.
A Malaysian node of the international Human Variome Project (HVP, is a consortium entrusted with the responsibility of conducting the study. The consortium comprises 69 researchers from various institutions in the country including Universiti Sains Malaysia (USM), Universiti Malaya (UM), Universiti Kebangsaan Malaysia (UKM), Universiti Putra Malaysia (UPM), Universiti Teknologi MARA (UiTM), Universiti Islam Antarabangsa (UIA), Multimedia University (MMU), Universiti Sultan Zainal Abidin (UniSZA), Monash University Malaysia, Medical Genetics Society of Malaysia, Genetics Society of Malaysia, Sengenics, Synamatix, Malaysian Society of Bioinformatics And Computational Biology and Chemistry Department of Malaysia.
The goal of the project is to create a genome SNP database of the major ethnic groups in our country based on the proposed study of common diseases in Malaysia such as Thalassemia, G6PD deficiency, Tuberculosis, Helicobacter pylori infection and the susceptibility of diseases amongst respective ethnic population.Back to top
Genomics is the study of the genome of an individual. Genome is the entirety of a person's hereditary information encoded in the DNA. The field of genomics includes research and identification of the entire DNA sequence variation of the individual and fine-scale genetic mapping efforts.
Genomic variations in the human DNA sequences can affect the development of diseases and an individual's response to drugs, infections and vaccines. One of these genomic variations is the single nucleotide polymorphism or SNP.
In biomedical research, identification of these genomic variations will enable researchers to conduct comparative studies between matched cohorts with and without a particular disease. Discovery of these variations will provide fundamental new insights into the pathogenesis, diagnosis and treatment of human diseases and towards the development of personalized medicine.Back to top
In Malaysia, the various ethnic groups show different patterns of historical migrations and speak languages which belong to the branches of the Austroasiatic and Austronesian tree. However, cultures in Malaysia have steadily transcended the communities of ethnicity over the centuries. Hence, the proposed Malaysian Node of Human Genome Variome Project is threefold:
(1) To create a reliable and extensive national genomics database of ethnicities in the country
(2) To create a phenotype database of genetic diseases common to respective ethnics community
(3) To examine the ethical, legal and social implications on the Malaysian society.Back to top
Our objectives are :
(1) To create the human genome variation map of the major ethnic groups in Malaysia.
(2) To study implications of mapping on ethical, legal and social issues (ELSI), pharmacogenomics, nutrigenomics, toxicogenomics, archeogenomics, forensics, genome wide disease association studies (GWAS) and the country's migration history.Back to top